Chapter 4: Tissue Engineering and Regenerative Therapies

Journal articles

https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.1100090504/ (free)

Seminal paper by Arnold Caplan that defines the mesenchymal stem cells and discusses their utility in the regeneration of cartilage.

https://www.isct-cytotherapy.org/article/S1465-3249(06)70881-7/fulltext/ (paid)

A definition paper describing the cell surface markers that should be present to define a mesenchymal stem cell. This is a recognised position paper that was endorsed by the International Society for Cell & Gene Therapy.

https://academic.oup.com/stcltm/article/6/6/1445/6448531/ (free)

Paper by Arnold Caplan, in which he proposes the redefinition of mesenchymal stem cells as medicinal signalling cells, on the basis that they seem to exhibit the capacity to migrate to the site of injured tissue.

https://www.nature.com/articles/d41586-018-06756-9/ (free)

A paper that outlines the current confusion around what constitutes a mesenchymal stem cell. A tighter definition was suggested in order to ensure that what is used medically is quality assured.

https://www.isct-cytotherapy.org/article/S1465-3249(19)30841-2/fulltext/ (paid)

Clarification of the definition of what constitutes a mesenchymal stem cell, with the suggestion that, in addition to surface markers, they are characterised using functional assays and considering tissue of origin.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292498/ (free)

Definition of standardised assays that should be used for the characterisation of stem cell products that are to be used clinically.

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