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Multiple Choice Question 1 of 5
Which of the following cell types are not available in autogenous form?CorrectIncorrect
Multiple Choice Question 2 of 5
The first tissue-engineered skin replacement was reported by Rheinwald and Green (1975). In order to trigger the keratinocyte layer to stratify, they …CorrectIncorrect
Multiple Choice Question 3 of 5
Which material type allows for ready cell encapsulation owing to ready diffusion of nutrients and waste products?CorrectIncorrect
Multiple Choice Question 4 of 5
The overproduction of which cytokine results in the migration of myofibroblasts into the wound?CorrectIncorrect
Multiple Choice Question 5 of 5
Give one major problem with biotherapeutics that can be used to modulate fibrosis?CorrectIncorrect
Seminal paper by Arnold Caplan that defines the mesenchymal stem cells and discusses their utility in the regeneration of cartilage.
A definition paper describing the cell surface markers that should be present to define a mesenchymal stem cell. This is a recognised position paper that was endorsed by the International Society for Cell & Gene Therapy.
Paper by Arnold Caplan, in which he proposes the redefinition of mesenchymal stem cells as medicinal signalling cells, on the basis that they seem to exhibit the capacity to migrate to the site of injured tissue.
A paper that outlines the current confusion around what constitutes a mesenchymal stem cell. A tighter definition was suggested in order to ensure that what is used medically is quality assured.
Clarification of the definition of what constitutes a mesenchymal stem cell, with the suggestion that, in addition to surface markers, they are characterised using functional assays and considering tissue of origin.
Definition of standardised assays that should be used for the characterisation of stem cell products that are to be used clinically.