Chapter 11: Tissue and Molecular Diagnosis

Journal articles

Early pathology

https://link.springer.com/article/10.1007%2Fs00428-011-1075-0/ (paid)

This paper revisits the story of the alleged failure of a famous nineteenth century German pathologist to diagnose laryngeal cancer in a biopsy from the Kaiser. The death of the Kaiser from cancer after the negative result apparently led to scepticism in Europe about the value of histopathology.

Mismatch repair deficiency

https://pubmed.ncbi.nlm.nih.gov/34837268/ (paid)

This review provides practical information on clinical testing and the interpretation of microsatellite instability/mismatch repair testing.


https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S1470204519301548?returnurl=https:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1470204519301548%3Fshowall%3Dtrue&referrer=https:%2F%2Fdiagnosticpathology.biomedcentral.com%2F/ (paid)

In modern clinical practice, digital pathology is playing an increasingly important role. Rapid technological advancements are likely to enable improved diagnosis and clinical care. This review article discusses these important advances in digital pathology and artificial intelligence.


https://www.esp-pathology.org/_Resources/Persistent/c8aea6fb029803c787160deaba164e82f82c4f75/ESP%20Position%20Paper.pdf (free)

This position paper from the European Society of Pathology describes the integral role of diagnostic pathology in molecular test performance and molecular interpretations.

Book chapters


Pathology has a crucial role in the accessibility and delivery of quality health care. This is because the field of pathology is responsible for diagnosis and is the most common diagnostic gold standard. This chapter reviews the essential minimal requirements to provide access to pathology services.


Colorectal cancer


This guideline describes the minimum requirements for colorectal carcinoma pathological evaluation and reporting.

Non-neoplastic gastrointestinal pathology


This guideline describes the typical workflows by which digestive system biopsies and resections are managed and important recommendations for handling.

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