Chapter 1: Metabolic Response to Injury

Journal articles

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342478/ (free)

Paper describing the effects of using b-blocker to block the adrenergic hyperactivation that drives adverse stress responses.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105702/ (free)

Review article summarising current knowledge on the roles of inflammasomes and damage-associated molecular patterns (DAMPs) in trauma.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078999/ (free)

Contemporary human study on multiple organ dysfunction syndrome (MODS) subtypes in trauma critical care at a population level. Describes incidence of MODS, patterns of severity and recovery, their admission characteristics.

https://www.clinicalnutritionjournal.com/article/S0261-5614(05)00023-3/fulltext/ (paid)

Seminal consensus review article describing enhanced recovery after surgery (ERAS) for patients undergoing colonic resection but with broader clinical applications.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027646/ (free)

Review describing responses to trauma in relation to chest, abdomen and head injury, plus the endothelium as a ‘meta-organ’, and their interrelated changes in innate immunity after trauma.

https://academic.oup.com/jcem/article/95/9/4217/2835313/ (free)

Authoritative editorial on insulin resistance and surgical outcomes, insulin resistance being one of the most fundamental reactions to injury and stress.

https://jamanetwork.com/journals/jamasurgery/fullarticle/2595921/ (free)

Authoritative review of impact of enhanced recovery after surgery (ERAS) as an evidence-based care improvement process for surgical patients, describing major improvements in clinical outcomes and cost.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693769/ (free)

Study of incidence and risk factors of chronic critical illness (CCI) after severe blunt trauma. CCI is defined as an ICU stay lasting ≥14 days with evidence of persistent organ dysfunction.

https://www.nature.com/articles/ncpendmet0071/ (paid)

Review article describing the endocrine aspects of acute and prolonged critical illness.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013556/ (free)

Review summarising current knowledge regarding damage-associated molecular pattern (DAMP)-mediated systemic inflammatory response syndrome (SIRS) or immunosuppression and the clinical consequences in terms of organ failure and infections.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1422623/ (free) Classic and authoritative review of surgical and traumatic stress, pathways and outcomes.

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